#1 Eye Care Professional recommended
brand for dry eye in Canada1
The ONLY triple-action,
preservative-free formula
that provides up to 12
hours of dry eye relief1*
*47% of patients experience meaningful symptom relief at 12 hours, N=153.
#1 Eye Care Professional recommended brand for dry eye in Canada1
The ONLY triple-action, preservative-free formula that provides up to 12 hours of dry eye relief1*
*47% of patients experience meaningful symptom relief at 12 hours, N=153.
Why Systane® PRO?
Clinically proven to provide up to 12 hours of dry eye symptom relief1*
Triple action dry eye symptom relief formulated with hyaluronic acid to hydrate, restore and protect1
Designed to treat all types of dry eye—aqueous, evaporative, and mixed1
Contact lens friendly—safe for use with soft contact lenses†
*47% of patients experience meaningful symptom relief at 12 hours, N=153.
†Not a rewetting solution.
What’s behind the Systane® PRO formula?
HP-guar
Interacts with borate to act as a “bandage” to support healing of corneal epithelial cells2,3*
Hyaluronic acid
Is included in the formula that provides lasting moisture retention and hydration1,4
Lipids
Reduces tear evaporation and enhances tear film stability5†
Propylene glycol
Is the demulcent that lubricates and soothes dry eyes1
How does Systane® PRO deliver triple-action relief?
Hydrates
Enriched with hyaluronic acid to instantly hydrate eyes1
Restores
Contains lipids, which help restore the tear film to prevent further evaporation1‡
Protects
Protects from dryness for up to 12 hours1§
*In vitro data. Based on Systane® ORIGINAL formulation.
†In vitro data. Based on Systane® COMPLETE formulation.
‡Improvement in NITBUT demonstrated at Day 30 compared to baseline. Dosed 4 times a day. N=316; (p<0.0001).
§47% of patients experienced meaningful symptom relief at 12 hours, N=153; Dose: 1 drop at Day 1.
See how Systane® PRO works
Clinically proven to provide rapid relief from the first drop1
Systane® PRO demonstrated a significant reduction in DES score immediately after instillation (p<0.0001)*
Systane® PRO Delivers up to 12 hours of dry eye symptom relief1†
*85% of the subjects showed ≥ 7-point improvement in DES Immediately after instillation; N=160.
†47% of patients experience meaningful symptom relief at 12 hours, N=153; Dose: 1 drop at Day 1.
DES=dry eye syndrome; SE=standard error.
Recommend the triple action formula of Systane® PRO for up to 12 hours of dry eye relief*
*47% of patients experience meaningful symptom relief at 12 hours, N=153; Dose: 1 drop at Day 1.
Explore the rest of the
SYSTANE® portfolio
Explore the rest of the
SYSTANE® portfolio
References:
1. Alcon data on file, 2025.
2. Kesavan S, Prud’homme RK. Rheology of guar and (hydroxypropyl) guar crosslinked by borate. Macromolecules. 1992;25(7):2026-2032.
3. Ubels JL, et al. Pre-clinical investigation of the efficacy of an artificial tear solution containing hydroxypropyl-guar as a gelling agent. Curr Eyes Res. 2004;28(6):437-444.
4. Rangarajan R, et al. Effects of a hyaluronic acid/hydroxypropyl guar artificial tear solution on protection, recovery, and lubricity in models of corneal epithelium. J Ocul Pharmacol Ther. 2015;31(8):491-497.
5. Rangarajan R, Ketelson H. Preclinical evaluation of a new hydroxypropyl-guar phospholipid nanoemulsion-based artificial tear formulation in models of corneal epithelium. J Ocul Pharmacol Ther. 2019;35(1):32-37.
